The Histology Guide


Fibroblasts secrete collagen and elastin; fibres in the extracellular matrix (ECM).

(Fibra - latin for fibre, blastos - greek for germ)

They are the least specialised of the connective tissue cells and can differentiate into other cell types found in the ECM.

Fibroblasts are spindle shaped, and actively secreting matrix. Their cytoplasm is basophilic, so there will be quite a lot of purplish blue staining of the cytoplasm, using the H&E stain.

Adults tend to have less active fibroblasts, called fibrocytes, which have paler stained cytoplasm.

This is a picture of an active fibroblasts. Note the prominent nucleus, and nucleoli, granular cytoplasm and cellular extensions.

diagram of fibroblasts


photo of a fibroblast

Fibroblasts can remodel the ECM, stretching out collagen fibres for example, as shown here. diagram of ECM

Connective tissue repair is carried out by new fibroblasts which are derived from cells called pericytes. The new fibroblasts migrate into wounds, following injury, and help repair the damage.

Contractile fibroblasts, called myofibroblasts are also often generated, and these help to contract wounds.