to form the supporting framework of some organs, such as
the walls of airways (nose, trachea, larynx and bronchi), where
it prevents airway collapse.
to form the articulating surfaces of bones, and
to form the template for the growth and development of long
bones, and most of the rest of the fetal skeleton (gradually
replaced by bone). In children, the cartilaginous plates at the
ends of long bones can be seen on X-rays. These templates disappear
when adults reach their full height.
Constituents of cartilage.
Cartilageis a strong, flexible and semi-rigid supporting
tissue. It can withstand compression forces, and yet it can bend.
It is made up of cells called chondroblasts
and chondrocytes, (chondro - cartilage)and extracellular matrix, made up about
10% aggrecan, 75% water, and a mix of collagen
fibres and other constituents.
There are three types of cartilage, which differ mostly in the
type of fibres they contain.
Hyaline: Most common - has a glassy appearance
(hyalos - is greek for glass).
Fibrocartilage: tendon insertions and invertebral
discs: reinforced with parallel bundles of collagen fibres.
Elastic cartilage: external ear and epiglottis:
flexible and resilient - has elastic fibres as well as collagen
Click here to find out more
about these three types.
This diagram shows the structure of an aggregate of Aggrecan
(another name for the aggregating GAG chondroitin sulphate).
Aggrecan is only found in cartilage. The aggregates contain
up to 100 molecules of chondroitin sulphate (shown in purple) are
bound to one molecule of hyaluronic acid (shown in red).
Importance of Extracellular matrix
The extracellular matrix soaks up water, like a sponge, (osmotic effect) due to the properties of the GAG: aggrecan, producing the high water content (75%).
The collagen fibres form a network which has a very high tensile strength, and which entraps the aggrecan molecules.
When you stand up or walk, the weight of your body is supported by the cartilagenous ends of the long bones. In this state your weight compresses the cartilage, literally squeezing the water out, until the force produced by the osmotic swelling is equal to the compressive force generated by your weight.
The extracellular matrix of cartilage is secreted by chondroblasts,
(chondro = cartilage), which are found in the outer covering layer
of cartilage. As the chondroblasts secrete matrix and fibres, they
become trapped inside it, and mature into cells called chondrocytes.
(See diagram opposite)
In growing cartilage, the chondrocytes can divide, and the
daughter cells remain close together in groups, forming a 'nest'
of 2-4 cells. The matrix enclosed compartments that they sit in
are called lacunae. (lacunae = little lakes/small
pits). The active chondrocytes are large secretory cells with basophilic cytoplasm because they have lots of rough endoplasmic reticulum.
Older chondrocytes contain fat droplets.
(Fixation of cartilage usually causes some shrinkage between the
cell border and the lacunar wall, so that these lacunae look more
prominent in fixed tissue.)
The surface of most cartilage is covered by a layer of dense
irregular connective tissue called the perichondrium
(peri = around). The outer layer of the perichondrium contains collagen
producing fibroblasts, and the inner layer contains chondroblasts.
This is a photograph of a section of hyaline cartilage, showing the chondrocytes trapped in lacunae in the matrix
Growth and nourishment of cartilage:
Unlike other connective tissues cartilage is avascular
(like epithelia). Cartilage is nourished by long range
diffusion from nearby capillaries in the perichondrium. Therefore, cartilage can never become very thick, as diffusion would
not be sufficient to supply the cartilage with nutrients and oxygen.
(This is in contrast to bone, because bone has a very good blood
Cartilage can grow in two ways: Interstitial growth
- chondrocytes grow and divide and lay down more matrix inside
the existing cartilage. This mainly happens during childhood and
adolescence. Appositional growth - new surface
layers of matrix are added to the pre-existing matrix by new chondroblasts
from the perichondrium.